ISJ Theoretical & Applied Science 11(67) 2018

Philadelphia, USA

Huseynova, A. S., Hajiyev, A. H., Efendiyev, A. M., & Kerimova, I. A.

Proinflammatory cytokines in Rheumatoid arthritis: relationship with vitamin D deficiency.

Full Article: PDF

Scientific Object Identifier: http://s-o-i.org/1.1/TAS-11-67-62

DOI: https://dx.doi.org/10.15863/TAS.2018.11.67.62

Language: Russian

Citation: Huseynova, A. S., Hajiyev, A. H., Efendiyev, A. M., & Kerimova, I. A. (2018). Proinflammatory cytokines in Rheumatoid arthritis: relationship with vitamin D deficiency. ISJ Theoretical & Applied Science, 11 (67), 348-352. Soi: http://s-o-i.org/1.1/TAS-11-67-62 Doi: https://dx.doi.org/10.15863/TAS.2018.11.67.62

Pages: 348-352

Published: 30.11.2018

Abstract: The article presents the results of the study the relationship between the level of inflammatory cytokines (TNF- , IL-2, IL-6, IL-8) and vitamin D in patients with rheumatoid arthritis (RA). 74 patients with RA at the age from 27 to 71 years were examined. The control group consisted of 16 healthy individuals. The results of our research have shown high levels of proinflammatory cytokines in both seropositive and seronegative RF groups of patients with RA compared to control. High production of cytokines in both groups was combined with a low level of vitamin D. The significant negative correlation of vitamin D was detected with the level of the main proinflammatory cytokines, TNF- and IL-6. Vitamin D deficiency may be one of the factors complicating the progress of rheumatoid arthritis, which confirms the use of this vitamin in the complex therapy of this disease.

Key words: rheumatoid arthritis, cytokines, interleukins, tumor necrosis factor, vitamin D.