ISJ Theoretical & Applied Science



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SOI: 1.1/TAS         DOI: 10.15863/TAS

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ISJ Theoretical & Applied Science 02(34) 2016

ISPC Technology and Innovation, Philadelphia, USA

* Scientific Article * Impact Factor 6.630

Atia AJ, Al-Marjani MF, Qaban MA


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Language: English

Citation: Atia AJ, Al-Marjani MF, Qaban MA (2016) ANTIFUNGAL ACTIVITY OF SOME NEW i-LACTAM AND IMIDAZOLE DERIVATIVES. ISJ Theoretical & Applied Science, 02 (34): 7-20. Soi: Doi:

Pages: 7-20

Published: 29.02.2016

Abstract: Trichophyton mentagrophytes causes a variety of infections in both animals and humans. It is a zoophilic fungus and most human diseases are contacted from animals. It is of worldwide distribution and has a very wide range of hosts. The aim of this study was to evaluate the antifungal activity of compounds of derivatives (C4) and (C7) in vivo and in vitro. The antifungal activity was determined by the agar method against T. mentagrophytes. Derivatives were synthesized by the reaction of cinnamic acid with thionyl chloride to give the corresponding acid chloride (C1). Carbohydrazide (C2) was obtained by the reaction of (C1) with hydrazine hydrate. Compound (C2) undergoes the character condensation reaction with aromatic aldehyde(4-bromobenzaldehyde) in absolute ethanol gave the Schiffis base (C3). Treating a phenyl acetic acid in triethyl amine with (C3) in the presence of SOCl2 to form the appropriate i-lactams (C4). Reaction of compound (C1) with glycine in sodium hydroxide solution gave acid (C5). Oxazole derivative (C6) was synthesized by the reaction of (C5) with aromatic aldehydes (2-chlorobenzaldehyde) in acetic acid and acetic anhydride. Imidazole derivatives (C7) was synthesized by the reaction of Hydrazine hydrate with (C6) in dry benzene. The product compounds were characterized by FT-IR, U.V and 1HNMR spectra .The results showed that cyclic compound had highly effect against T. mentagrophytes (in vitro) and in treatment skin infection (in vivo) when the healing was occur after 10 days compare with control.

Key words: Trichophyton mentagrophytes, i-lactams, Imidazole.








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